Interactions between the cannabinoid and the serotonergic systems in modulation of pain perception

The aim of our study was to evaluate the effects cannabinoids and serotonergic system on nociception in intact rats after heat stress. Cannabinoid receptor type 1 (CB1) 5-hydroxytryptamine (5НТ 1А ) agonists antagonists have been administered according different experimental designs (alone combinations) male Wistar rats, as well animals subjected one hour Pain perception has evaluated by Paw pressure test. Our results pointed out that interact Cannabinoids seemed less prominent role such interaction than interplay between two systems probably involves mechanisms stress with time-dependent effects. cannabinoid exerts a modulating rather mediating effect h-SIA.